Background: Depression is a common psychiatric condition that negatively affects feeling, thinking and acting. The present study was conducted to assess serum S100B level in patient with depression.
Materials and Methods: 86 patients of depression of both genders were enrolled. Group I comprised of depression patients and group II had control. The severity of depression was assessed using Beck’s depression inventory-II (BDI), Hamilton depression rating scale (HAM- D) and stressful life event scale (SLES). Serum S100B levels were measured using Sandwich ELISA.
Results: The mean BDI scale was 28.4 in group I, 2.1 in group II. HAM- D was 20.4 in group I and 1.6 in group II and SLES was 5.7 in group I and 2.4 in group II. The difference was significant (P< 0.05). The mean S100B level in group I males was 98.1 pg/ml and in females was 93.4 pg/ml and in group II males was 67.1 pg/ml and in females was 26.9 pg/ml. The difference was significant (P< 0.05).
Conclusion: Serum S100B level was elevated in depression patients as compared to control subjects.